To make these Pumpkin Cream Cheese Muffins with Swirl Filling gluten-free, replace the all-purpose flour in both the muffin batter and streusel topping with a certified gluten-free 1:1 baking flour blend. Use certified gluten-free pumpkin pie spice, baking powder, baking soda, vanilla extract, and all other packaged ingredients. Confirm that the cream cheese, sour cream, and pumpkin puree are gluten-free and free from cross-contamination. For best results, use clean utensils, bowls, and muffin pans that have not come into contact with gluten-containing ingredients.