To make this Orange Pound Cake gluten free, replace the all-purpose flour with a reliable 1:1 gluten-free baking flour blend that contains xanthan gum or a similar binder. Also confirm that the baking powder, baking soda, confectioners’ sugar, vanilla extract, and any packaged ingredients are labeled gluten free, since brands may vary or be processed in shared facilities. If your gluten-free flour blend does not already include a binder, you may need to add a small amount of xanthan gum to help maintain the loaf’s structure. For anyone with celiac disease or severe gluten sensitivity, use clean loaf pans, bowls, mixers, parchment, cooling racks, and utensils to avoid cross-contact.