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Mac and Cheese Meatloaf Casserole served hot with crisp edges and gooey center

Mac and Cheese Meatloaf Casserole

Mac and Cheese Meatloaf Casserole made with ground beef, buttermilk, onion soup mix, eggs, breadcrumbs, barbecue sauce, ketchup, elbow pasta, cheddar soup, evaporated milk, mozzarella, and cheddar.
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Course: Casserole, Dinner, Main Course
Cuisine: American, Comfort Food
Keyword: Mac and Cheese Meatloaf Casserole
Prep Time: 20 minutes
Cook Time: 1 hour
Total Time: 1 hour 20 minutes
Servings: 9

Ingredients

Meatloaf Layer

  • 2 lb ground beef 85/15
  • 1 c buttermilk or milk
  • 2 packets onion soup mix
  • 2 large eggs
  • 1 c breadcrumbs
  • 1/2 c barbecue sauce
  • 1/2 c ketchup

Mac and Cheese Layer

  • 16 oz dry elbow pasta
  • 10 oz can cheddar cheese soup
  • 12 oz evaporated milk
  • 8 oz mozzarella cheese grated, about 2 c
  • 4 oz sharp cheddar cheese grated, about 1 c

Instructions

Preheat the oven.

  • Preheat the oven to 350°F.

Prepare the meatloaf mixture.

  • In a large mixing bowl, combine the ground beef, onion soup mix, breadcrumbs, buttermilk or milk, and eggs. Mix until just combined.

Prepare the glaze.

  • In a small bowl, stir together the barbecue sauce and ketchup until smooth.

Form the meatloaf layer.

  • Transfer the meatloaf mixture to a baking dish. Press it evenly into the bottom of the dish.

Add the glaze.

  • Spread the barbecue sauce and ketchup mixture evenly over the meatloaf layer.

Bake the meatloaf layer.

  • Place the baking dish in the oven and bake for 30 minutes.

Prepare the cheese sauce.

  • While the meatloaf layer is baking, combine the cheddar cheese soup and evaporated milk in a bowl. Stir until smooth.

Prepare the cheeses.

  • Grate the mozzarella cheese and sharp cheddar cheese. Set aside.

Cook the pasta.

  • Approximately 15 minutes before the meatloaf layer is finished baking, cook the elbow pasta according to package directions. Drain well.

Combine pasta and sauce.

  • In a large bowl, combine the cooked elbow pasta with the cheddar cheese soup mixture and 1 c of the grated mozzarella cheese. Stir until evenly coated.

Add the mac and cheese layer.

  • Remove the baking dish from the oven. Spread the prepared mac and cheese evenly over the baked meatloaf layer.

Top with remaining cheese.

  • Sprinkle the remaining mozzarella cheese and the sharp cheddar cheese evenly over the top of the casserole.

Bake the casserole.

  • Return the baking dish to the oven and bake for 20 minutes, or until the casserole is heated through and the cheese is melted.

Broil the top.

  • If desired, broil for 1 to 3 minutes, or until the cheese topping is lightly browned. Watch carefully to prevent burning.

Cool before serving.

  • Remove the casserole from the oven and allow it to rest for several minutes before serving.

Notes

To make this Mac and Cheese Meatloaf Casserole gluten free, replace the breadcrumbs with certified gluten-free breadcrumbs and use certified gluten-free elbow pasta. Verify that the onion soup mix, barbecue sauce, ketchup, cheddar cheese soup, evaporated milk, cheeses, and all packaged ingredients are labeled gluten free. Use clean bowls, utensils, cookware, and baking dishes to prevent cross-contact with gluten-containing ingredients.