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Savory baked casserole with ground beef, peppers, and melted cheddar served on a white plate.

Cattle Drive Casserole

This Cattle Drive Casserole is a hearty baked dinner with seasoned ground beef, peppers, tomatoes, a creamy cheesy topping, and a tender Bisquick crust. It is comforting, flavorful, and perfect for busy family meals or casual gatherings.
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Course: Casserole, Main Course
Cuisine: American, Tex-Mex
Keyword: Cattle Drive Casserole
Prep Time: 15 minutes
Cook Time: 30 minutes
Total Time: 45 minutes
Servings: 6

Ingredients

  • 2 1/2 cups Bisquick
  • 1 cup water
  • 1 1/2 pounds ground beef
  • 1 can Rotel fire-roasted tomatoes with green chiles
  • 1 can 4 ounces green chiles
  • 1 packet taco seasoning mix
  • 1 red pepper diced
  • 1 onion diced
  • 1/2 cup sour cream
  • 1/2 cup mayonnaise
  • 1 teaspoon garlic powder
  • 1 3/4 cups cheddar cheese shredded
  • Salt to taste
  • Black pepper to taste

Instructions

Preheat the oven.

  • Preheat the oven to 350°F. Lightly spray a 9 x 13-inch baking dish with nonstick cooking spray.

Cook the beef and vegetables.

  • In a skillet over medium heat, cook the ground beef, diced onion, and diced red pepper until the beef is fully cooked and the vegetables are tender. Stir in the taco seasoning, and season with salt and black pepper to taste.

Prepare the creamy topping.

  • In a medium bowl, combine the mayonnaise, sour cream, garlic powder, and a portion of the shredded cheddar cheese. Mix until smooth.

Prepare the crust.

  • In a separate bowl, combine the Bisquick and water, adding a small amount of additional water if necessary to form a soft dough.

Pre-bake the crust.

  • Press the dough evenly into the bottom of the prepared baking dish. Bake for 5 to 7 minutes, or until lightly golden.

Add the meat layer.

  • Remove the crust from the oven and spread the cooked meat and vegetable mixture evenly over the crust.

Add the tomato layer.

  • Spoon the tomatoes and green chiles evenly over the meat layer.

Add the creamy topping.

  • Spread the sour cream mixture evenly over the tomato layer.

Finish with cheese.

  • Sprinkle the remaining shredded cheddar cheese over the top.

Bake the casserole.

  • Return the dish to the oven and bake for an additional 30 minutes, or until the casserole is hot and bubbly and the cheese is melted.

Serve.

  • Remove from the oven and allow the casserole to rest briefly before serving.

Notes

To make this recipe gluten free, replace the Bisquick with a certified gluten-free baking mix, and confirm that the taco seasoning, Rotel tomatoes, green chiles, mayonnaise, sour cream, and shredded cheese are all labeled gluten free or free from cross-contact concerns. Some packaged seasoning mixes and baking blends may contain hidden gluten or wheat-based thickeners, so checking labels matters here. If preparing the casserole in a shared kitchen, use clean pans, utensils, and prep surfaces to help prevent gluten contamination.